3e7v: Difference between revisions

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-{{Seed}}
-[[Image:3e7v.png|left|200px]]
-<!--
+==Crystal Structure of Human Haspin with a pyrazolo-pyrimidine ligand==
-The line below this paragraph, containing "STRUCTURE_3e7v", creates the "Structure Box" on the page.
+<StructureSection load='3e7v' size='340' side='right'caption='[[3e7v]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3e7v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7V FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DZO:3-(3-AMINOPHENYL)-N-(3-CHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDIN-5-AMINE'>DZO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-{{STRUCTURE_3e7v|  PDB=3e7v  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7v OCA], [https://pdbe.org/3e7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7v RCSB], [https://www.ebi.ac.uk/pdbsum/3e7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HASP_HUMAN HASP_HUMAN] Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.<ref>PMID:11228240</ref> <ref>PMID:15681610</ref> <ref>PMID:17084365</ref> <ref>PMID:20705812</ref> <ref>PMID:20929775</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7v_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7v ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of Human Haspin with a pyrazolo-pyrimidine ligand===
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-E7V is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7V OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Arrowsmith CH]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Bountra C]]
-[[Category: Bountra, C.]]
+[[Category: Burgess-Brown N]]
-[[Category: Burgess-Brown, N.]]
+[[Category: Edwards AM]]
-[[Category: Delft, F Von.]]
+[[Category: Eswaran J]]
-[[Category: Edwards, A M.]]
+[[Category: Fedorov O]]
-[[Category: Eswaran, J.]]
+[[Category: Filippakopoulos P]]
-[[Category: Fedorov, O.]]
+[[Category: Keates T]]
-[[Category: Filippakopoulos, P.]]
+[[Category: Knapp S]]
-[[Category: Keates, T.]]
+[[Category: Pike ACW]]
-[[Category: Knapp, S.]]
+[[Category: Wickstroem M]]
-[[Category: Pike, A C.W.]]
+[[Category: Von Delft F]]
-[[Category: SGC, Structural Genomics Consortium.]]
-[[Category: Wickstroem, M.]]
-[[Category: Alternative splicing]]
-[[Category: Atp-binding]]
-[[Category: Cell cycle]]
-[[Category: Chromatin regulator]]
-[[Category: Haploid germ cell specific nuclear protein kinase]]
-[[Category: Haspin]]
-[[Category: Kinase]]
-[[Category: Magnesium]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Serine/threonine-protein kinase]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 29 09:43:07 2008''