3e77: Difference between revisions

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-[[Image:3e77.png|left|200px]]
-{{STRUCTURE_3e77|  PDB=3e77  |  SCENE=  }}
+==Human phosphoserine aminotransferase in complex with PLP==
+<StructureSection load='3e77' size='340' side='right'caption='[[3e77]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-===Human phosphoserine aminotransferase in complex with PLP===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3e77]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E77 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-[[3e77]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E77 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e77 OCA], [https://pdbe.org/3e77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e77 RCSB], [https://www.ebi.ac.uk/pdbsum/3e77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e77 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN] Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:[https://omim.org/entry/610992 610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.<ref>PMID:17436247</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e77_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e77 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Phosphoserine aminotransferase|Phosphoserine aminotransferase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Phosphoserine transaminase]]
+[[Category: Large Structures]]
-[[Category: Andersson, J.]]
+[[Category: Andersson J]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Berg, S Van Den.]]
+[[Category: Berglund H]]
-[[Category: Berglund, H.]]
+[[Category: Bountra C]]
-[[Category: Bountra, C.]]
+[[Category: Collins R]]
-[[Category: Collins, R.]]
+[[Category: Dahlgren LG]]
-[[Category: Dahlgren, L G.]]
+[[Category: Edwards AM]]
-[[Category: Edwards, A M.]]
+[[Category: Flodin S]]
-[[Category: Flodin, S.]]
+[[Category: Flores A]]
-[[Category: Flores, A.]]
+[[Category: Graslund S]]
-[[Category: Graslund, S.]]
+[[Category: Hammarstrom M]]
-[[Category: Hammarstrom, M.]]
+[[Category: Johansson A]]
-[[Category: Johansson, A.]]
+[[Category: Johansson I]]
-[[Category: Johansson, I.]]
+[[Category: Karlberg T]]
-[[Category: Karlberg, T.]]
+[[Category: Kotenyova T]]
-[[Category: Kotenyova, T.]]
+[[Category: Lehtio L]]
-[[Category: Lehtio, L.]]
+[[Category: Moche M]]
-[[Category: Moche, M.]]
+[[Category: Nilsson ME]]
-[[Category: Nilsson, M E.]]
+[[Category: Nordlund P]]
-[[Category: Nordlund, P.]]
+[[Category: Nyman T]]
-[[Category: Nyman, T.]]
+[[Category: Olesen K]]
-[[Category: Olesen, K.]]
+[[Category: Persson C]]
-[[Category: Persson, C.]]
+[[Category: Sagemark J]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Schueler H]]
-[[Category: Sagemark, J.]]
+[[Category: Thorsell SG]]
-[[Category: Schueler, H.]]
+[[Category: Tresaugues L]]
-[[Category: Thorsell, S G.]]
+[[Category: Van Den Berg S]]
-[[Category: Tresaugues, L.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Welin M]]
-[[Category: Welin, M.]]
+[[Category: Wikstrom M]]
-[[Category: Wikstrom, M.]]
+[[Category: Wisniewska M]]
-[[Category: Wisniewska, M.]]
-[[Category: Amino-acid biosynthesis]]
-[[Category: Aminotransferase]]
-[[Category: Disease mutation]]
-[[Category: Phosphoserine aminotransferase]]
-[[Category: Plp]]
-[[Category: Pyridoxal phosphate]]
-[[Category: Serc]]
-[[Category: Serine biosynthesis]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Transferase]]