3e70: Difference between revisions

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-[[Image:3e70.png|left|200px]]
-{{STRUCTURE_3e70|  PDB=3e70  |  SCENE=  }}
+==Structures and conformations in solution of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus Furiosus==
+<StructureSection load='3e70' size='340' side='right'caption='[[3e70]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3e70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E70 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e70 OCA], [https://pdbe.org/3e70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e70 RCSB], [https://www.ebi.ac.uk/pdbsum/3e70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e70 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8U051_PYRFU Q8U051_PYRFU] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) (By similarity).[HAMAP-Rule:MF_00920]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In all organisms, a ribonucleoprotein called the signal recognition particle (SRP) and its receptor (SR) target nascent proteins from the ribosome to the translocon for secretion or membrane insertion. We present the first X-ray structures of an archeal FtsY, the receptor from the hyper-thermophile Pyrococcus furiosus (Pfu), in its free and GDP*magnesium-bound forms. The highly charged N-terminal domain of Pfu-FtsY is distinguished by a long N-terminal helix. The basic charges on the surface of this helix are likely to regulate interactions at the membrane. A peripheral GDP bound near a regulatory motif could indicate a site of interaction between the receptor and ribosomal or SRP RNAs. Small angle X-ray scattering and analytical ultracentrifugation indicate that the crystal structure of Pfu-FtsY correlates well with the average conformation in solution. Based on previous structures of two sub-complexes, we propose a model of the core of archeal and eukaryotic SRP*SR targeting complexes.
-===Structures and conformations in solution of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus Furiosus===
+Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane.,Egea PF, Tsuruta H, de Leon GP, Napetschnig J, Walter P, Stroud RM PLoS ONE. 2008;3(11):e3619. Epub 2008 Nov 3. PMID:18978942<ref>PMID:18978942</ref>
-{{ABSTRACT_PUBMED_18978942}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3e70" style="background-color:#fffaf0;"></div>
-[[3e70]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E70 OCA].
 ==See Also==
 *[[Signal recognition particle receptor|Signal recognition particle receptor]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:018978942</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Pyrococcus furiosus]]
-[[Category: Egea, P F.]]
+[[Category: Egea PF]]
-[[Category: Napetschnig, J.]]
+[[Category: Napetschnig J]]
-[[Category: Stroud, R M.]]
+[[Category: Stroud RM]]
-[[Category: Tsuruta, H.]]
+[[Category: Tsuruta H]]
-[[Category: Walter, P]]
+[[Category: Walter P]]
-[[Category: Ftsy]]
-[[Category: Protein-targeting]]
-[[Category: Signal recognition particle receptor]]
-[[Category: Srp-gtpase]]
-[[Category: Transport protein]]