3e4e: Difference between revisions

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 ==Human cytochrome P450 2E1 in complex with the inhibitor 4-methylpyrazole==
-<StructureSection load='3e4e' size='340' side='right' caption='[[3e4e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+<StructureSection load='3e4e' size='340' side='right'caption='[[3e4e]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3e4e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E4E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3e4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E4E FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PZ:4-METHYL-1H-PYRAZOLE'>4PZ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2E1, CYP2E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4PZ:4-METHYL-1H-PYRAZOLE'>4PZ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4e OCA], [https://pdbe.org/3e4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4e RCSB], [https://www.ebi.ac.uk/pdbsum/3e4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4e ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4e OCA], [http://pdbe.org/3e4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e4e RCSB], [http://www.ebi.ac.uk/pdbsum/3e4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4e ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CP2E1_HUMAN CP2E1_HUMAN]] Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
+[https://www.uniprot.org/uniprot/CP2E1_HUMAN CP2E1_HUMAN] Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 31: @@
 ==See Also==
-*[[Cytochrome P450|Cytochrome P450]]
+*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
-*[[Drug Metabolism by CYP450 Enzymes|Drug Metabolism by CYP450 Enzymes]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Unspecific monooxygenase]]
+[[Category: Large Structures]]
-[[Category: Meneely, K M]]
+[[Category: Meneely KM]]
-[[Category: Porubsky, P R]]
+[[Category: Porubsky PR]]
-[[Category: Scott, E E]]
+[[Category: Scott EE]]
-[[Category: Acetaminophen]]
-[[Category: Cyp2e1]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Heme]]
-[[Category: Iron]]
-[[Category: Membrane]]
-[[Category: Metal-binding]]
-[[Category: Microsome]]
-[[Category: Monooxygenase]]
-[[Category: Oxidoreductase]]
-[[Category: P450 2e1]]