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==Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and D-malate==
==Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and D-malate==
<StructureSection load='3d47' size='340' side='right' caption='[[3d47]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3d47' size='340' side='right'caption='[[3d47]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3d47]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D47 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3d47]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D47 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3box|3box]], [[3d46|3d46]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yfaW, STM2291 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d47 OCA], [https://pdbe.org/3d47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d47 RCSB], [https://www.ebi.ac.uk/pdbsum/3d47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d47 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3d47 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d47 OCA], [http://pdbe.org/3d47 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d47 RCSB], [http://www.ebi.ac.uk/pdbsum/3d47 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d47 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3d47 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RHMD_SALTY RHMD_SALTY]] Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.<ref>PMID:18754693</ref>
[https://www.uniprot.org/uniprot/RHMD_SALTY RHMD_SALTY] Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.<ref>PMID:18754693</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Salty]]
[[Category: Large Structures]]
[[Category: Almo, S C]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Burley, S K]]
[[Category: Almo SC]]
[[Category: Fedorov, A A]]
[[Category: Burley SK]]
[[Category: Fedorov, E V]]
[[Category: Fedorov AA]]
[[Category: Gerlt, J A]]
[[Category: Fedorov EV]]
[[Category: Structural genomic]]
[[Category: Gerlt JA]]
[[Category: Sauder, J M]]
[[Category: Sauder JM]]
[[Category: L-rhamnonate dehydratase]]
[[Category: Lyase]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]
[[Category: Target 9265a]]

Latest revision as of 15:40, 30 August 2023

Crystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and D-malateCrystal structure of L-rhamnonate dehydratase from Salmonella typhimurium complexed with Mg and D-malate

Structural highlights

3d47 is a 8 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RHMD_SALTY Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR). Can also dehydrate L-lyxonate and L-mannonate, although less efficiently, but not 2-keto-4-hydroxyheptane-1,7-dioate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA. Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase. Biochemistry. 2008 Sep 23;47(38):9944-54. Epub 2008 Aug 29. PMID:18754693 doi:10.1021/bi800914r

3d47, resolution 1.80Å

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