3ckl: Difference between revisions

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New page: left|200px {{Structure |PDB= 3ckl |SIZE=350|CAPTION= <scene name='initialview01'>3ckl</scene>, resolution 2.0Å |SITE= <scene name='pdbsite=AC1:Stl+Binding+Site+F...
 
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[[Image:3ckl.jpg|left|200px]]


{{Structure
==Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol==
|PDB= 3ckl |SIZE=350|CAPTION= <scene name='initialview01'>3ckl</scene>, resolution 2.0&Aring;
<StructureSection load='3ckl' size='340' side='right'caption='[[3ckl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Stl+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Stl+Binding+Site+For+Residue+B+501'>AC2</scene>, <scene name='pdbsite=AC3:A3p+Binding+Site+For+Residue+A+601'>AC3</scene> and <scene name='pdbsite=AC4:A3p+Binding+Site+For+Residue+B+601'>AC4</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene>
<table><tr><td colspan='2'>[[3ckl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CKL FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
|GENE= SULT1B1, ST1B2, SULT1B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=STL:RESVERATROL'>STL</scene></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00685 Sulfotransfer_1]</span>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [https://pdbe.org/3ckl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB], [https://www.ebi.ac.uk/pdbsum/3ckl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ckl ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckl OCA], [http://www.ebi.ac.uk/pdbsum/3ckl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3ckl RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/ST1B1_HUMAN ST1B1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.<ref>PMID:9443824</ref> <ref>PMID:9463486</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/3ckl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ckl ConSurf].
<div style="clear:both"></div>


'''Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol'''
==See Also==
 
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
 
== References ==
==About this Structure==
<references/>
3CKL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CKL OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Dong, A.]]
[[Category: Dong A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Kozieradzki, I.]]
[[Category: Kozieradzki I]]
[[Category: Loppnau, P.]]
[[Category: Loppnau P]]
[[Category: Min, J.]]
[[Category: Min J]]
[[Category: Pan, P W.]]
[[Category: Pan PW]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: cytoplasm]]
[[Category: human cytosolic sulfotransferase]]
[[Category: lipid metabolism]]
[[Category: polymorphism]]
[[Category: resveratrol]]
[[Category: sgc]]
[[Category: steroid metabolism]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: sult1b1]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  2 12:00:21 2008''

Latest revision as of 15:29, 30 August 2023

Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrolCrystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol

Structural highlights

3ckl is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ST1B1_HUMAN Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Fujita K, Nagata K, Ozawa S, Sasano H, Yamazoe Y. Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. J Biochem. 1997 Nov;122(5):1052-61. PMID:9443824
  2. ↑ Wang J, Falany JL, Falany CN. Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. Mol Pharmacol. 1998 Feb;53(2):274-82. PMID:9463486

3ckl, resolution 2.00Å

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