3cfr: Difference between revisions

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{{Seed}}
[[Image:3cfr.jpg|left|200px]]


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==Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 2==
The line below this paragraph, containing "STRUCTURE_3cfr", creates the "Structure Box" on the page.
<StructureSection load='3cfr' size='340' side='right'caption='[[3cfr]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3cfr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_RB69 Escherichia phage RB69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
{{STRUCTURE_3cfr| PDB=3cfr |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfr OCA], [https://pdbe.org/3cfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfr RCSB], [https://www.ebi.ac.uk/pdbsum/3cfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfr ConSurf].
<div style="clear:both"></div>


===Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 2===
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3CFR is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_rb69 Enterobacteria phage rb69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFR OCA].
[[Category: Escherichia phage RB69]]
 
[[Category: Large Structures]]
==Reference==
[[Category: Klimenko D]]
<ref group="xtra">PMID:9215631</ref><ref group="xtra">PMID:11389835</ref><references group="xtra"/>
[[Category: Konigsberg WH]]
[[Category: DNA-directed DNA polymerase]]
[[Category: Steitz TA]]
[[Category: Enterobacteria phage rb69]]
[[Category: Wang J]]
[[Category: Klimenko, D.]]
[[Category: Wang M]]
[[Category: Konigsberg, W H.]]
[[Category: Steitz, T A.]]
[[Category: Wang, J.]]
[[Category: Wang, M.]]
[[Category: Catalytic complex]]
[[Category: Dna polymerase]]
[[Category: Fidelity]]
[[Category: Transferase/dna complex]]
[[Category: Two metal ion mechanism]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 11:23:18 2009''

Latest revision as of 15:28, 30 August 2023

Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 2Structure of the replicating complex of a POL Alpha family DNA Polymerase, ternary complex 2

Structural highlights

3cfr is a 3 chain structure with sequence from Escherichia phage RB69. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPOL_BPR69 This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3cfr, resolution 2.40Å

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