3c72: Difference between revisions

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-{{Seed}}
-[[Image:3c72.png|left|200px]]
-<!--
+==Engineered RabGGTase in complex with a peptidomimetic inhibitor==
-The line below this paragraph, containing "STRUCTURE_3c72", creates the "Structure Box" on the page.
+<StructureSection load='3c72' size='340' side='right'caption='[[3c72]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3c72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C72 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CX1:N-[(BENZYLOXY)CARBONYL]-L-HISTIDYL-N-METHYL-L-PHENYLALANYL-L-TYROSINE'>CX1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3c72|  PDB=3c72  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c72 OCA], [https://pdbe.org/3c72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c72 RCSB], [https://www.ebi.ac.uk/pdbsum/3c72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c72 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c72_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c72 ConSurf].
+<div style="clear:both"></div>
-===Engineered RabGGTase in complex with a peptidomimetic inhibitor===
+==See Also==
+*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-C72 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA].
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:18399557</ref><references group="xtra"/>
-[[Category: Protein geranylgeranyltransferase type II]]
 [[Category: Rattus norvegicus]]
-[[Category: Alexandrov, K.]]
+[[Category: Alexandrov K]]
-[[Category: Arndt, S.]]
+[[Category: Arndt S]]
-[[Category: Blankenfeldt, W.]]
+[[Category: Blankenfeldt W]]
-[[Category: Bon, R S.]]
+[[Category: Bon RS]]
-[[Category: Delon, C.]]
+[[Category: Delon C]]
-[[Category: Goody, R S.]]
+[[Category: Goody RS]]
-[[Category: Guiu-Rozas, E.]]
+[[Category: Guiu-Rozas E]]
-[[Category: Guo, Z.]]
+[[Category: Guo Z]]
-[[Category: Nguyen, U T.]]
+[[Category: Nguyen UT]]
-[[Category: Tan, K T.]]
+[[Category: Tan KT]]
-[[Category: Waldmann, H.]]
+[[Category: Waldmann H]]
-[[Category: Wetzel, S.]]
+[[Category: Wetzel S]]
-[[Category: Wu, Y W.]]
+[[Category: Wu YW]]
-[[Category: Metal-binding]]
-[[Category: Peptide inhibitor]]
-[[Category: Phosphoprotein]]
-[[Category: Prenyltransferase]]
-[[Category: Rab prenylation]]
-[[Category: Transferase]]
-[[Category: Zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 07:35:15 2009''