3c5c: Difference between revisions

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-[[Image:3c5c.jpg|left|200px]]
- {{Structure
+==Crystal structure of human Ras-like, family 12 protein in complex with GDP==
-|PDB= 3c5c |SIZE=350|CAPTION= <scene name='initialview01'>3c5c</scene>, resolution 1.850&Aring;
+<StructureSection load='3c5c' size='340' side='right'caption='[[3c5c]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+202'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+B+202'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+C+202'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Residue+D+202'>AC4</scene>, <scene name='pdbsite=AC5:Mg+Binding+Site+For+Residue+A+203'>AC5</scene>, <scene name='pdbsite=AC6:Mg+Binding+Site+For+Residue+C+203'>AC6</scene>, <scene name='pdbsite=AC7:Mg+Binding+Site+For+Residue+B+203'>AC7</scene>, <scene name='pdbsite=AC8:Gdp+Binding+Site+For+Residue+A+201'>AC8</scene>, <scene name='pdbsite=AC9:Gdp+Binding+Site+For+Residue+B+201'>AC9</scene>, <scene name='pdbsite=BC1:Gdp+Binding+Site+For+Residue+C+201'>BC1</scene>, <scene name='pdbsite=BC2:Gdp+Binding+Site+For+Residue+D+201'>BC2</scene>, <scene name='pdbsite=BC3:Unx+Binding+Site+For+Residue+A+204'>BC3</scene>, <scene name='pdbsite=BC4:Unx+Binding+Site+For+Residue+D+203'>BC4</scene> and <scene name='pdbsite=BC5:Unx+Binding+Site+For+Residue+C+204'>BC5</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=UNX:UNKNOWN ATOM OR ION'>UNX</scene>
+<table><tr><td colspan='2'>[[3c5c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5C FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
-|GENE= RASL12, RIS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5c OCA], [https://pdbe.org/3c5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5c RCSB], [https://www.ebi.ac.uk/pdbsum/3c5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5c ProSAT]</span></td></tr>
+</table>
-'''Crystal structure of human Ras-like, family 12 protein in complex with GDP'''
+== Function ==
+[https://www.uniprot.org/uniprot/RASLC_HUMAN RASLC_HUMAN]
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-C5C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5C OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5c_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5c ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bochkarev, A.]]
+[[Category: Bochkarev A]]
-[[Category: Bountra, C.]]
+[[Category: Bountra C]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Loppnau, P.]]
+[[Category: Loppnau P]]
-[[Category: Park, H.]]
+[[Category: Park H]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Shen L]]
-[[Category: Shen, L.]]
+[[Category: Tempel W]]
-[[Category: Tempel, W.]]
+[[Category: Tong Y]]
-[[Category: Tong, Y.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
-[[Category: GDP]]
-[[Category: MG]]
-[[Category: UNX]]
-[[Category: gdp]]
-[[Category: gtp-binding]]
-[[Category: gtpase]]
-[[Category: limited proteolysis]]
-[[Category: nucleotide-binding]]
-[[Category: ra]]
-[[Category: rasl12]]
-[[Category: sgc]]
-[[Category: signaling protein]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:02:37 2008''