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==Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution== | ==Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution== | ||
<StructureSection load='3bwc' size='340' side='right' caption='[[3bwc]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3bwc' size='340' side='right'caption='[[3bwc]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3bwc]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3bwc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BWC FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bwc OCA], [https://pdbe.org/3bwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bwc RCSB], [https://www.ebi.ac.uk/pdbsum/3bwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bwc ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | [https://www.uniprot.org/uniprot/Q4DA73_TRYCC Q4DA73_TRYCC] | ||
<table> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/3bwc_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/3bwc_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bwc ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Spermidine | *[[Spermidine synthase 3D structures|Spermidine synthase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi strain CL Brener]] | ||
[[Category: Arakaki | [[Category: Arakaki TL]] | ||
[[Category: Bosch | [[Category: Bosch J]] | ||
[[Category: Hol | [[Category: Hol WGJ]] | ||
[[Category: Le Trong I]] | |||
[[Category: Merritt EA]] | |||
[[Category: Trong | |||
[[Category: | |||
Latest revision as of 15:17, 30 August 2023
Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolutionCrystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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