3boj: Difference between revisions

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-{{Seed}}
-[[Image:3boj.png|left|200px]]
-<!--
+==Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 1 without bound metal (CDCA1-R1)==
-The line below this paragraph, containing "STRUCTURE_3boj", creates the "Structure Box" on the page.
+<StructureSection load='3boj' size='340' side='right'caption='[[3boj]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3boj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conticribra_weissflogii Conticribra weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BOJ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-{{STRUCTURE_3boj|  PDB=3boj  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3boj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3boj OCA], [https://pdbe.org/3boj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3boj RCSB], [https://www.ebi.ac.uk/pdbsum/3boj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3boj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q50EL4_THAWE Q50EL4_THAWE]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Carbonic anhydrase, a zinc enzyme found in organisms from all kingdoms, catalyses the reversible hydration of carbon dioxide and is used for inorganic carbon acquisition by phytoplankton. In the oceans, where zinc is nearly depleted, diatoms use cadmium as a catalytic metal atom in cadmium carbonic anhydrase (CDCA). Here we report the crystal structures of CDCA in four distinct forms: cadmium-bound, zinc-bound, metal-free and acetate-bound. Despite lack of sequence homology, CDCA is a structural mimic of a functional beta-carbonic anhydrase dimer, with striking similarity in the spatial organization of the active site residues. CDCA readily exchanges cadmium and zinc at its active site--an apparently unique adaptation to oceanic life that is explained by a stable opening of the metal coordinating site in the absence of metal. Given the central role of diatoms in exporting carbon to the deep sea, their use of cadmium in an enzyme critical for carbon acquisition establishes a remarkable link between the global cycles of cadmium and carbon.
-===Carbonic anhydrase from marine diatom Thalassiosira weissflogii- cadmium bound domain 1 without bound metal (CDCA1-R1)===
+Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms.,Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM Nature. 2008 Mar 6;452(7183):56-61. PMID:18322527<ref>PMID:18322527</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3boj" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_18322527}}, adds the Publication Abstract to the page
+*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 18322527 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_18322527}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Conticribra weissflogii]]
-BOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thalassiosira_weissflogii Thalassiosira weissflogii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BOJ OCA].
+[[Category: Large Structures]]
+[[Category: Feng L]]
-==Reference==
+[[Category: Jeffrey PD]]
-Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms., Xu Y, Feng L, Jeffrey PD, Shi Y, Morel FM, Nature. 2008 Mar 6;452(7183):56-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18322527 18322527]
+[[Category: Morel FMM]]
-[[Category: Single protein]]
+[[Category: Shi Y]]
-[[Category: Thalassiosira weissflogii]]
+[[Category: Xu Y]]
-[[Category: Feng, L.]]
-[[Category: Jeffrey, P D.]]
-[[Category: Morel, F M.M.]]
-[[Category: Shi, Y.]]
-[[Category: Xu, Y.]]
-[[Category: Apo form]]
-[[Category: Carbonic anhydrase]]
-[[Category: Marine diatom]]
-[[Category: Oxidoreductase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:01:52 2008''