3bgv: Difference between revisions

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[[Image:3bgv.png|left|200px]]


{{STRUCTURE_3bgv|  PDB=3bgv  |  SCENE=  }}
==Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH==
 
<StructureSection load='3bgv' size='340' side='right'caption='[[3bgv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3bgv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGV FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
[[3bgv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGV OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgv OCA], [https://pdbe.org/3bgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgv RCSB], [https://www.ebi.ac.uk/pdbsum/3bgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgv ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Antoshenko, T.]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Antoshenko T]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Edwards, A M.]]
[[Category: Bochkarev A]]
[[Category: Lunin, V V.]]
[[Category: Edwards AM]]
[[Category: MacKenzie, F.]]
[[Category: Lunin VV]]
[[Category: Min, J.]]
[[Category: MacKenzie F]]
[[Category: Plotnikov, A N.]]
[[Category: Min J]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Plotnikov AN]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Wu, H.]]
[[Category: Wu H]]
[[Category: Zeng, H.]]
[[Category: Zeng H]]
[[Category: Methyltransferase]]
[[Category: Mrna capping]]
[[Category: Mrna processing]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Rna-binding]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]

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