3bfx: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:3bfx.jpg|left|200px]]<br /><applet load="3bfx" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="3bfx, resolution 1.80&Aring;" />
-'''Crystal structure of human sulfotransferase SULT1C1 in complex with PAP'''<br />
-==About this Structure==
+==Crystal structure of human sulfotransferase SULT1C1 in complex with PAP==
-BFX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=A3P:'>A3P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. This structure superseeds the now removed PDB entries 2ETG and 1ZHE. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFX OCA].
+<StructureSection load='3bfx' size='340' side='right'caption='[[3bfx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3bfx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2etg 2etg] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1zhe 1zhe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BFX FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bfx OCA], [https://pdbe.org/3bfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bfx RCSB], [https://www.ebi.ac.uk/pdbsum/3bfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bfx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ST1C2_HUMAN ST1C2_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hyroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bf/3bfx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bfx ConSurf].
+<div style="clear:both"></div>
-==Reference==
+==See Also==
-Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP)., Dombrovski L, Dong A, Bochkarev A, Plotnikov AN, Proteins. 2006 Sep 1;64(4):1091-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16804942 16804942]
+*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bochkarev, A.]]
+[[Category: Bochkarev A]]
-[[Category: Dombrovski, L.]]
+[[Category: Dombrovski L]]
-[[Category: Dong, A.]]
+[[Category: Dong A]]
-[[Category: Edwards, A.M.]]
+[[Category: Edwards AM]]
-[[Category: Loppnau, P.]]
+[[Category: Loppnau P]]
-[[Category: Plotnikov, A.N.]]
+[[Category: Plotnikov AN]]
-[[Category: SGC, Structural.Genomics.Consortium.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
-[[Category: A3P]]
-[[Category: alternative splicing]]
-[[Category: cytoplasm]]
-[[Category: pap]]
-[[Category: polymorphism]]
-[[Category: protein structure initiative]]
-[[Category: psi]]
-[[Category: sgc]]
-[[Category: structural genomics]]
-[[Category: structural genomics consortium]]
-[[Category: sulfotransferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 11:55:26 2008''