3b7x: Difference between revisions
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<StructureSection load='3b7x' size='340' side='right'caption='[[3b7x]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3b7x' size='340' side='right'caption='[[3b7x]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3b7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3b7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7X FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7x OCA], [https://pdbe.org/3b7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7x RCSB], [https://www.ebi.ac.uk/pdbsum/3b7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7x OCA], [https://pdbe.org/3b7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7x RCSB], [https://www.ebi.ac.uk/pdbsum/3b7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] PPIases accelerate the folding of proteins. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | |||
[[Category: Arrowsmith | [[Category: Bochkarev A]] | ||
[[Category: Bochkarev | [[Category: Butler-Cole C]] | ||
[[Category: Butler-Cole | [[Category: Davis T]] | ||
[[Category: Davis | [[Category: Dhe-Paganon S]] | ||
[[Category: Dhe-Paganon | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Paramanathan R]] | ||
[[Category: Paramanathan | [[Category: Walker JR]] | ||
[[Category: Weigelt J]] | |||
[[Category: Walker | |||
[[Category: Weigelt | |||
Latest revision as of 15:04, 30 August 2023
Crystal structure of human FK506-Binding Protein 6Crystal structure of human FK506-Binding Protein 6
Structural highlights
DiseaseFKBP6_HUMAN Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. FunctionFKBP6_HUMAN PPIases accelerate the folding of proteins. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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