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[[Image:3b7x.gif|left|200px]]


{{Structure
==Crystal structure of human FK506-Binding Protein 6==
|PDB= 3b7x |SIZE=350|CAPTION= <scene name='initialview01'>3b7x</scene>, resolution 2.10&Aring;
<StructureSection load='3b7x' size='340' side='right'caption='[[3b7x]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[3b7x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B7X FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= FKBP6, FKBP36 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b7x OCA], [https://pdbe.org/3b7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b7x RCSB], [https://www.ebi.ac.uk/pdbsum/3b7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b7x ProSAT]</span></td></tr>
}}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
== Function ==
[https://www.uniprot.org/uniprot/FKBP6_HUMAN FKBP6_HUMAN] PPIases accelerate the folding of proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/3b7x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b7x ConSurf].
<div style="clear:both"></div>


'''Crystal structure of human FK506-Binding Protein 6'''
==See Also==
 
*[[FKBP 3D structures|FKBP 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3B7X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7X OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Butler-Cole C]]
[[Category: Butler-Cole, C.]]
[[Category: Davis T]]
[[Category: Davis, T.]]
[[Category: Dhe-Paganon S]]
[[Category: Dhe-Paganon, S.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Paramanathan R]]
[[Category: Paramanathan, R.]]
[[Category: Walker JR]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Walker, J R.]]
[[Category: Weigelt, J.]]
[[Category: isomerase]]
[[Category: repeat]]
[[Category: rotamase]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
[[Category: tpr repeat]]
[[Category: williams-beuren syndrome]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:56:53 2008''

Latest revision as of 15:04, 30 August 2023

Crystal structure of human FK506-Binding Protein 6Crystal structure of human FK506-Binding Protein 6

Structural highlights

3b7x is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

FKBP6_HUMAN Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Function

FKBP6_HUMAN PPIases accelerate the folding of proteins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3b7x, resolution 2.10Å

Drag the structure with the mouse to rotate

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