2ypn: Difference between revisions

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-[[Image:2ypn.gif|left|200px]]
- {{Structure
+==Hydroxymethylbilane synthase==
-|PDB= 2ypn |SIZE=350|CAPTION= <scene name='initialview01'>2ypn</scene>, resolution 2.3&Aring;
+<StructureSection load='2ypn' size='340' side='right'caption='[[2ypn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=DPM:3-{2-[4-(2-CARBOXY-ETHYL)-3-CARBOXYMETHYL-5H-PYRROL-2-YLMETHYL]-4-CARBOXYMETHYL-5-METHYL-2H-PYRROL-3-YL}-PROPIONIC+ACID'>DPM</scene>
+<table><tr><td colspan='2'>[[2ypn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YPN FirstGlance]. <br>
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylbilane_synthase Hydroxymethylbilane synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.61 2.5.1.61] </span>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPM:3-[5-{[3-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)-5-METHYL-1H-PYRROL-2-YL]METHYL}-4-(CARBOXYMETHYL)-1H-PYRROL-3-YL]PROPANOIC+ACID'>DPM</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ypn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypn OCA], [https://pdbe.org/2ypn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ypn RCSB], [https://www.ebi.ac.uk/pdbsum/2ypn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ypn ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ypn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ypn OCA], [http://www.ebi.ac.uk/pdbsum/2ypn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ypn RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/HEM3_ECOLI HEM3_ECOLI] Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.[HAMAP-Rule:MF_00260]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yp/2ypn_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ypn ConSurf].
+<div style="clear:both"></div>
-'''Hydroxymethylbilane synthase'''
+==See Also==
+*[[Porphobilinogen Deaminase|Porphobilinogen Deaminase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-YPN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPN OCA].
 [[Category: Escherichia coli]]
-[[Category: Hydroxymethylbilane synthase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Campbell JW]]
-[[Category: Campbell, J W.]]
+[[Category: Habash J]]
-[[Category: Habash, J.]]
+[[Category: Haedener A]]
-[[Category: Haedener, A.]]
+[[Category: Hao Q]]
-[[Category: Hao, Q.]]
+[[Category: Helliwell JR]]
-[[Category: Helliwell, J R.]]
+[[Category: Nieh YP]]
-[[Category: Nieh, Y P.]]
+[[Category: Raftery J]]
-[[Category: Raftery, J.]]
+[[Category: Schotte F]]
-[[Category: Schotte, F.]]
+[[Category: Ursby T]]
-[[Category: Ursby, T.]]
+[[Category: Weisgerber S]]
-[[Category: Weisgerber, S.]]
+[[Category: Wulff M]]
-[[Category: Wulff, M.]]
-[[Category: all alpha/beta]]
-[[Category: biosynthesis of linear tetrapyrrole]]
-[[Category: lyase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:14:21 2008''