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==Crystal Structure of Human TL1A Extracellular Domain C95S Mutant==
==Crystal Structure of Human TL1A Extracellular Domain C95S Mutant==
<StructureSection load='2rjk' size='340' side='right' caption='[[2rjk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2rjk' size='340' side='right'caption='[[2rjk]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RJK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJK FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2qe3|2qe3]], [[2rjl|2rjl]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjk OCA], [https://pdbe.org/2rjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjk RCSB], [https://www.ebi.ac.uk/pdbsum/2rjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjk OCA], [http://pdbe.org/2rjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rjk RCSB], [http://www.ebi.ac.uk/pdbsum/2rjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TNF15_HUMAN TNF15_HUMAN]] Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.<ref>PMID:9872942</ref> <ref>PMID:11923219</ref> <ref>PMID:11911831</ref> <ref>PMID:10597252</ref>
[https://www.uniprot.org/uniprot/TNF15_HUMAN TNF15_HUMAN] Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.<ref>PMID:9872942</ref> <ref>PMID:11923219</ref> <ref>PMID:11911831</ref> <ref>PMID:10597252</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjk_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rjk_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2rjk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2rjk" style="background-color:#fffaf0;"></div>
==See Also==
*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C]]
[[Category: Large Structures]]
[[Category: Bonanno, J]]
[[Category: Almo SC]]
[[Category: Nathenson, S G]]
[[Category: Bonanno J]]
[[Category: Patskovsky, Y]]
[[Category: Nathenson SG]]
[[Category: Ramagopal, U A]]
[[Category: Patskovsky Y]]
[[Category: Shi, W]]
[[Category: Ramagopal UA]]
[[Category: Toro, R]]
[[Category: Shi W]]
[[Category: Yan, Q]]
[[Category: Toro R]]
[[Category: Zhan, C]]
[[Category: Yan Q]]
[[Category: Cytokine]]
[[Category: Zhan C]]
[[Category: Membrane]]
[[Category: Mutant]]
[[Category: Tl1a]]
[[Category: Tnfsf]]
[[Category: Transmembrane]]

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