2rf5: Difference between revisions

<StructureSection load='2rf5' size='340' side='right'caption='[[2rf5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[2rf5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF5 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf5 OCA], [https://pdbe.org/2rf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf5 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf5 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TNKS1_HUMAN TNKS1_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1.<ref>PMID:10988299</ref> <ref>PMID:11739745</ref> <ref>PMID:16076287</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref> <ref>PMID:22864114</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rf5_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rf5 ConSurf].

*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Berglund H]]

[[Category: Busam R]]

[[Category: Collins R]]

[[Category: Dahlgren LG]]

[[Category: Edwards AM]]

[[Category: Flodin S]]

[[Category: Flores A]]

[[Category: Graslund S]]

[[Category: Hammarstrom M]]

[[Category: Herman MD]]

[[Category: Holmberg-Schiavone L]]

[[Category: Johansson I]]

[[Category: Kallas A]]

[[Category: Karlberg T]]

[[Category: Kotenyova T]]

[[Category: Lehtio L]]

[[Category: Moche M]]

[[Category: Nordlund P]]

[[Category: Nyman T]]

[[Category: Persson C]]

[[Category: Sagemark J]]

[[Category: Sundstrom M]]

[[Category: Thorsell AG]]

[[Category: Tresaugues L]]

[[Category: Weigelt J]]

[[Category: Welin M]]

[[Category: Van den Berg S]]