2rf0: Difference between revisions

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[[Image:2rf0.png|left|200px]]


{{STRUCTURE_2rf0|  PDB=2rf0  |  SCENE=  }}
==Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain==
 
<StructureSection load='2rf0' size='340' side='right'caption='[[2rf0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Crystal structure of human mixed lineage kinase MAP3K10 SH3 domain===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2rf0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF0 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
[[2rf0]] is a 4 chain structure of [[Mitogen-activated protein kinase kinase kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF0 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf0 OCA], [https://pdbe.org/2rf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M3K10_HUMAN M3K10_HUMAN] Activates the JUN N-terminal pathway (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rf0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rf0 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mitogen-activated protein kinase kinase kinase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Berridge, G.]]
[[Category: Berridge G]]
[[Category: Delft, F von.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Eswaran J]]
[[Category: Eswaran, J.]]
[[Category: Keates T]]
[[Category: Keates, T.]]
[[Category: Knapp S]]
[[Category: Knapp, S.]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W.]]
[[Category: Savitsky P]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Savitsky, P.]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Ugochukwu, E.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: Atp-binding]]
[[Category: Map3k10]]
[[Category: Mkn28]]
[[Category: Mlk2]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Sgc]]
[[Category: Sh3 domain]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Tkl kinase]]
[[Category: Transferase]]

Latest revision as of 14:55, 30 August 2023

Crystal structure of human mixed lineage kinase MAP3K10 SH3 domainCrystal structure of human mixed lineage kinase MAP3K10 SH3 domain

Structural highlights

2rf0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

M3K10_HUMAN Activates the JUN N-terminal pathway (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rf0, resolution 2.00Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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