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[[Image:2r4h.png|left|200px]]


{{STRUCTURE_2r4h|  PDB=2r4h  |  SCENE=  }}
==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase==
 
<StructureSection load='2r4h' size='340' side='right'caption='[[2r4h]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
===Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4H FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr>
[[2r4h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [https://pdbe.org/2r4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [https://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Guanylate kinase|Guanylate kinase]]
*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Cooper, C.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F von.]]
[[Category: Cooper C]]
[[Category: Doyle, D A.]]
[[Category: Doyle DA]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Elkins, J M.]]
[[Category: Elkins JM]]
[[Category: Hozjan, V.]]
[[Category: Hozjan V]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: Pilka, E S.]]
[[Category: Pilka ES]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Ugochukwu E]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Atp-binding]]
[[Category: Cell junction]]
[[Category: Membrane associated guanylate kinase]]
[[Category: Nucleotide-binding]]
[[Category: Pdz]]
[[Category: Phosphorylation]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Tight junction]]
[[Category: Transferase]]

Latest revision as of 14:45, 30 August 2023

Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinaseCrystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase

Structural highlights

2r4h is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MAGI1_HUMAN May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2r4h, resolution 2.05Å

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OCA
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