2q53: Difference between revisions

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[[Image:2q53.jpg|left|200px]]


{{Structure
==Ensemble refinement of the crystal structure of uncharacterized protein loc79017 from Homo sapiens==
|PDB= 2q53 |SIZE=350|CAPTION= <scene name='initialview01'>2q53</scene>, resolution 2.010&Aring;
<StructureSection load='2q53' size='340' side='right'caption='[[2q53]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[2q53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q53 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
|GENE= C7orf24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q53 OCA], [https://pdbe.org/2q53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q53 RCSB], [https://www.ebi.ac.uk/pdbsum/2q53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q53 ProSAT]</span></td></tr>
 
</table>
'''Ensemble refinement of the crystal structure of uncharacterized protein loc79017 from Homo sapiens'''
== Function ==
 
[https://www.uniprot.org/uniprot/GGCT_HUMAN GGCT_HUMAN] Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.<ref>PMID:16765912</ref> <ref>PMID:18515354</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2Q53 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q53 OCA].  
Check<jmol>
 
  <jmolCheckbox>
==Reference==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q53_consurf.spt"</scriptWhenChecked>
Crystal structure of Homo sapiens protein LOC79017., Bae E, Bingman CA, Aceti DJ, Phillips GN Jr, Proteins. 2008 Feb 1;70(2):588-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17932939 17932939]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q53 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Kondrashov DA]]
[[Category: Jr., G N.Phillips.]]
[[Category: Levin EJ]]
[[Category: Kondrashov, D A.]]
[[Category: Phillips Jr GN]]
[[Category: Levin, E J.]]
[[Category: Wesenberg GE]]
[[Category: Wesenberg, G E.]]
[[Category: center for eukaryotic structural genomic]]
[[Category: cesg]]
[[Category: ensemble refinement]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: refinement methodology development]]
[[Category: structural genomic]]
[[Category: unknown function]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:21:50 2008''

Latest revision as of 14:20, 30 August 2023

Ensemble refinement of the crystal structure of uncharacterized protein loc79017 from Homo sapiensEnsemble refinement of the crystal structure of uncharacterized protein loc79017 from Homo sapiens

Structural highlights

2q53 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.01Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GGCT_HUMAN Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Masuda Y, Maeda S, Watanabe A, Sano Y, Aiuchi T, Nakajo S, Itabe H, Nakaya K. A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol. Biochem Biophys Res Commun. 2006 Jul 28;346(2):454-60. PMID:16765912 doi:http://dx.doi.org/S0006-291X(06)01180-6
  2. ↑ Oakley AJ, Yamada T, Liu D, Coggan M, Clark AG, Board PG. The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle. J Biol Chem. 2008 Aug 8;283(32):22031-42. Epub 2008 May 30. PMID:18515354 doi:10.1074/jbc.M803623200

2q53, resolution 2.01Å

Drag the structure with the mouse to rotate

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