2pn8: Difference between revisions

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[[Image:2pn8.png|left|200px]]


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==Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)==
The line below this paragraph, containing "STRUCTURE_2pn8", creates the "Structure Box" on the page.
<StructureSection load='2pn8' size='340' side='right'caption='[[2pn8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2pn8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PN8 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pn8 OCA], [https://pdbe.org/2pn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2pn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pn8 ProSAT]</span></td></tr>
{{STRUCTURE_2pn8| PDB=2pn8 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRDX4_HUMAN PRDX4_HUMAN] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<ref>PMID:9388242</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pn8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pn8 ConSurf].
<div style="clear:both"></div>


===Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)===
==See Also==
 
*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
 
== References ==
==About this Structure==
<references/>
2PN8 is a 10 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PN8 OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peroxiredoxin]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C A.]]
[[Category: Arrowsmith CA]]
[[Category: Cooper, C.]]
[[Category: Cooper C]]
[[Category: Delft, F von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Kavanagh KL]]
[[Category: Kavanagh, K L.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Pilka ES]]
[[Category: Pilka, E S.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: Oxidoreductase]]
[[Category: Peroxiredoxin]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Thioredoxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:26:42 2009''

Latest revision as of 14:05, 30 August 2023

Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)

Structural highlights

2pn8 is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PRDX4_HUMAN Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Jin DY, Chae HZ, Rhee SG, Jeang KT. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. J Biol Chem. 1997 Dec 5;272(49):30952-61. PMID:9388242

2pn8, resolution 1.80Å

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OCA
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