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[[Image:2pn8.gif|left|200px]]


{{Structure
==Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)==
|PDB= 2pn8 |SIZE=350|CAPTION= <scene name='initialview01'>2pn8</scene>, resolution 1.80&Aring;
<StructureSection load='2pn8' size='340' side='right'caption='[[2pn8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2pn8]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PN8 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
|GENE= PRDX4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pn8 OCA], [https://pdbe.org/2pn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pn8 RCSB], [https://www.ebi.ac.uk/pdbsum/2pn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pn8 ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRDX4_HUMAN PRDX4_HUMAN] Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.<ref>PMID:9388242</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pn/2pn8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pn8 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)'''
==See Also==
 
*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
 
== References ==
==About this Structure==
<references/>
2PN8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PN8 OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peroxiredoxin]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith CA]]
[[Category: Arrowsmith, C A.]]
[[Category: Cooper C]]
[[Category: Cooper, C.]]
[[Category: Edwards A]]
[[Category: Delft, F von.]]
[[Category: Kavanagh KL]]
[[Category: Edwards, A.]]
[[Category: Oppermann U]]
[[Category: Kavanagh, K L.]]
[[Category: Pilka ES]]
[[Category: Oppermann, U.]]
[[Category: Sundstrom M]]
[[Category: Pilka, E S.]]
[[Category: Weigelt J]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Von Delft F]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt, J.]]
[[Category: oxidoreductase]]
[[Category: peroxiredoxin]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
[[Category: thioredoxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:15:06 2008''

Latest revision as of 14:05, 30 August 2023

Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase)

Structural highlights

2pn8 is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PRDX4_HUMAN Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Jin DY, Chae HZ, Rhee SG, Jeang KT. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. J Biol Chem. 1997 Dec 5;272(49):30952-61. PMID:9388242

2pn8, resolution 1.80Å

Drag the structure with the mouse to rotate

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OCA
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