2pfr: Difference between revisions

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-[[Image:2pfr.gif|left|200px]]<br /><applet load="2pfr" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2pfr, resolution 1.920&Aring;" />
-'''Human N-acetyltransferase 2'''<br />
-==About this Structure==
+==Human N-acetyltransferase 2==
-PFR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=COA:'>COA</scene> and <scene name='pdbligand=UNX:'>UNX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Arylamine_N-acetyltransferase Arylamine N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.5 2.3.1.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFR OCA].
+<StructureSection load='2pfr' size='340' side='right'caption='[[2pfr]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
-[[Category: Arylamine N-acetyltransferase]]
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2pfr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PFR FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pfr OCA], [https://pdbe.org/2pfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pfr RCSB], [https://www.ebi.ac.uk/pdbsum/2pfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pfr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARY2_HUMAN ARY2_HUMAN] Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pf/2pfr_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pfr ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Arylamine N-acetyltransferase 3D structures|Arylamine N-acetyltransferase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bochkarev, A.]]
+[[Category: Bochkarev A]]
-[[Category: Dombrovski, L.]]
+[[Category: Dombrovski L]]
-[[Category: Edwards, A.M.]]
+[[Category: Edwards AM]]
-[[Category: Grant, D.M.]]
+[[Category: Grant DM]]
-[[Category: Loppnau, P.]]
+[[Category: Loppnau P]]
-[[Category: Plotnikov, A.N.]]
+[[Category: Plotnikov AN]]
-[[Category: SGC, Structural.Genomics.Consortium.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Tempel W]]
-[[Category: Tempel, W.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Wu H]]
-[[Category: Wu, H.]]
-[[Category: COA]]
-[[Category: SO4]]
-[[Category: UNX]]
-[[Category: arylamide acetylase 2]]
-[[Category: arylamine n-acetyltransferase 2]]
-[[Category: sgc]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:17:27 2008''