2pd6: Difference between revisions

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-[[Image:2pd6.jpg|left|200px]]
- {{Structure
+==Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8==
-|PDB= 2pd6 |SIZE=350|CAPTION= <scene name='initialview01'>2pd6</scene>, resolution 2.00&Aring;
+<StructureSection load='2pd6' size='340' side='right'caption='[[2pd6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
+<table><tr><td colspan='2'>[[2pd6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PD6 FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Estradiol_17-beta-dehydrogenase Estradiol 17-beta-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-|GENE= HSD17B8, FABGL, HKE6, RING2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pd6 OCA], [https://pdbe.org/2pd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pd6 RCSB], [https://www.ebi.ac.uk/pdbsum/2pd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pd6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DHB8_HUMAN DHB8_HUMAN] NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.<ref>PMID:17978863</ref> <ref>PMID:19571038</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pd/2pd6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pd6 ConSurf].
+<div style="clear:both"></div>
-'''Structure of human hydroxysteroid dehydrogenase type 8, HSD17B8'''
+==See Also==
+*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-PD6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PD6 OCA].
+__TOC__
-[[Category: Estradiol 17-beta-dehydrogenase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bunkoczi G]]
-[[Category: Delft, F von.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Gileadi O]]
-[[Category: Gileadi, O.]]
+[[Category: Guo K]]
-[[Category: Guo, K.]]
+[[Category: Oppermann U]]
-[[Category: Oppermann, U.]]
+[[Category: Pike ACW]]
-[[Category: Pike, A C.W.]]
+[[Category: Salah E]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Savitsky P]]
-[[Category: Salah, E.]]
+[[Category: Sundstrom M]]
-[[Category: Savitsky, P.]]
+[[Category: Turnbull AP]]
-[[Category: Sundstrom, M.]]
+[[Category: Ugochukwu E]]
-[[Category: Turnbull, A P.]]
+[[Category: Umeano C]]
-[[Category: Ugochukwu, E.]]
+[[Category: Weigelt J]]
-[[Category: Umeano, C.]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, J.]]
-[[Category: NAD]]
-[[Category: lipid metabolism]]
-[[Category: sgc]]
-[[Category: short-chain dehydrogenase/reductase]]
-[[Category: steroid metabolism]]
-[[Category: structural genomic]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:11:44 2008''