2p8e: Difference between revisions
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==Crystal structure of the serine/threonine phosphatase domain of human PPM1B== | ==Crystal structure of the serine/threonine phosphatase domain of human PPM1B== | ||
<StructureSection load='2p8e' size='340' side='right' caption='[[2p8e]], [[Resolution|resolution]] 1.82Å' scene=''> | <StructureSection load='2p8e' size='340' side='right'caption='[[2p8e]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p8e]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2p8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P8E FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.816Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8e OCA], [https://pdbe.org/2p8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p8e RCSB], [https://www.ebi.ac.uk/pdbsum/2p8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p8e ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2p8e TOPSAN]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/PPM1B_HUMAN PPM1B_HUMAN] 2p21 microdeletion syndrome. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PPM1B_HUMAN PPM1B_HUMAN] Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.<ref>PMID:18930133</ref> <ref>PMID:22750291</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8e_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/2p8e_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p8e ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 28: | Line 31: | ||
</div> | </div> | ||
<div class="pdbe-citations 2p8e" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2p8e" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Almo | [[Category: Almo SC]] | ||
[[Category: Bain | [[Category: Bain KT]] | ||
[[Category: Bonanno | [[Category: Bonanno JB]] | ||
[[Category: Burley | [[Category: Burley SK]] | ||
[[Category: Freeman | [[Category: Freeman J]] | ||
[[Category: Lau | [[Category: Lau C]] | ||
[[Category: Sauder JM]] | |||
[[Category: Sauder | [[Category: Smith D]] | ||
[[Category: Smith | [[Category: Wasserman S]] | ||
[[Category: Wasserman | [[Category: Xu W]] | ||
[[Category: Xu | |||