2ov2: Difference between revisions

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-[[Image:2ov2.gif|left|200px]]<br /><applet load="2ov2" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2ov2, resolution 2.10&Aring;" />
-'''The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)'''<br />
-==About this Structure==
+==The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)==
-OV2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=GCP:'>GCP</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OV2 OCA].
+<StructureSection load='2ov2' size='340' side='right'caption='[[2ov2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ov2]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OV2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ov2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ov2 OCA], [https://pdbe.org/2ov2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ov2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ov2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ov2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ov/2ov2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ov2 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Rac 3D structures|Rac 3D structures]]
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Protein complex]]
+[[Category: Arrowsmith CH]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Bunkoczi G]]
-[[Category: Bunkoczi, G.]]
+[[Category: Burgess-Brown N]]
-[[Category: Burgess-Brown, N.]]
+[[Category: Debreczeni JED]]
-[[Category: Debreczeni, J E.D.]]
+[[Category: Doyle DA]]
-[[Category: Delft, F von.]]
+[[Category: Edwards A]]
-[[Category: Doyle, D A.]]
+[[Category: Elkins JM]]
-[[Category: Edwards, A.]]
+[[Category: Knapp S]]
-[[Category: Elkins, J M.]]
+[[Category: Sundstrom M]]
-[[Category: Knapp, S.]]
+[[Category: Ugochukwu E]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Weigelt J]]
-[[Category: Sundstrom, M.]]
+[[Category: Yang X]]
-[[Category: Ugochukwu, E.]]
+[[Category: Von Delft F]]
-[[Category: Weigelt, J.]]
-[[Category: Yang, X.]]
-[[Category: CL]]
-[[Category: EDO]]
-[[Category: GCP]]
-[[Category: MG]]
-[[Category: crib]]
-[[Category: gtpase rac3]]
-[[Category: kinase]]
-[[Category: p21 rac]]
-[[Category: ras-related c3 botulinum toxin substrate 3]]
-[[Category: sgc]]
-[[Category: signalling protein]]
-[[Category: small gtp binding protein]]
-[[Category: structural genomics]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:22:48 2008''