2oo7: Difference between revisions

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-[[Image:2oo7.jpg|left|200px]]
- {{Structure
+==Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (T179I/Q199R)==
-|PDB= 2oo7 |SIZE=350|CAPTION= <scene name='initialview01'>2oo7</scene>, resolution 1.800&Aring;
+<StructureSection load='2oo7' size='340' side='right'caption='[[2oo7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+920'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+B+921'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+B+922'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Residue+A+923'>AC4</scene>, <scene name='pdbsite=AC5:Ap5+Binding+Site+For+Residue+A+1218'>AC5</scene> and <scene name='pdbsite=AC6:Ap5+Binding+Site+For+Residue+B+1219'>AC6</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=AP5:BIS(ADENOSINE)-5&#39;-PENTAPHOSPHATE'>AP5</scene>
+<table><tr><td colspan='2'>[[2oo7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OO7 FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-|GENE= adk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP5:BIS(ADENOSINE)-5-PENTAPHOSPHATE'>AP5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oo7 OCA], [https://pdbe.org/2oo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2oo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oo7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KAD_BACSU KAD_BACSU] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oo/2oo7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oo7 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (T179I/Q199R)'''
+==See Also==
+*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-OO7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OO7 OCA].
-[[Category: Adenylate kinase]]
 [[Category: Bacillus subtilis]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Counago, R.]]
+[[Category: Counago R]]
-[[Category: Myers, J C.]]
+[[Category: Myers JC]]
-[[Category: Shamoo, Y.]]
+[[Category: Shamoo Y]]
-[[Category: Wilson, C J.]]
+[[Category: Wilson CJ]]
-[[Category: Wittung-Stafshede, P.]]
+[[Category: Wittung-Stafshede P]]
-[[Category: Wu, G.]]
+[[Category: Wu G]]
-[[Category: AP5]]
-[[Category: MG]]
-[[Category: ZN]]
-[[Category: adenylate kinase]]
-[[Category: directed evolution]]
-[[Category: experimental adaptive evolution]]
-[[Category: thermostability]]
-[[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:33:58 2008''