2ome: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: left|200px<br /> <applet load="2ome" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ome, resolution 2.80Å" /> '''Crystal structure o...
 
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2ome.gif|left|200px]]<br />
<applet load="2ome" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2ome, resolution 2.80&Aring;" />
'''Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)'''<br />


==About this Structure==
==Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)==
2OME is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2OME OCA].  
<StructureSection load='2ome' size='340' side='right'caption='[[2ome]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ome]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OME FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ome FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ome OCA], [https://pdbe.org/2ome PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ome RCSB], [https://www.ebi.ac.uk/pdbsum/2ome PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ome ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CTBP2_HUMAN CTBP2_HUMAN] Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).  Isoform 2 probably acts as a scaffold for specialized synapses.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/2ome_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ome ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.H.]]
[[Category: Arrowsmith CH]]
[[Category: Debreczeni, J.E.]]
[[Category: Debreczeni JE]]
[[Category: Delft, F.von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Guo K]]
[[Category: Guo, K.]]
[[Category: Kavanagh KL]]
[[Category: Kavanagh, K.L.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Pilka ES]]
[[Category: Pilka, E.S.]]
[[Category: Rojkova A]]
[[Category: Rojkova, A.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural.Genomics.Consortium.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: NAD]]
[[Category: c-terminal binding protein]]
[[Category: ctbp2]]
[[Category: dehydrogenase]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:12:58 2007''

Latest revision as of 13:43, 30 August 2023

Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)

Structural highlights

2ome is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CTBP2_HUMAN Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2ome, resolution 2.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2ome&oldid=3853020"