2ome: Difference between revisions
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<StructureSection load='2ome' size='340' side='right'caption='[[2ome]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='2ome' size='340' side='right'caption='[[2ome]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ome]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ome]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OME FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ome FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ome OCA], [https://pdbe.org/2ome PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ome RCSB], [https://www.ebi.ac.uk/pdbsum/2ome PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ome ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ome FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ome OCA], [https://pdbe.org/2ome PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ome RCSB], [https://www.ebi.ac.uk/pdbsum/2ome PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ome ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CTBP2_HUMAN CTBP2_HUMAN] Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Debreczeni | [[Category: Debreczeni JE]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Guo K]] | ||
[[Category: Guo | [[Category: Kavanagh KL]] | ||
[[Category: Kavanagh | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Pilka ES]] | ||
[[Category: Pilka | [[Category: Rojkova A]] | ||
[[Category: Rojkova | [[Category: Sundstrom M]] | ||
[[Category: Weigelt J]] | |||
[[Category: Sundstrom | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||
Latest revision as of 13:43, 30 August 2023
Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)
Structural highlights
FunctionCTBP2_HUMAN Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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