2ojw: Difference between revisions

<StructureSection load='2ojw' size='340' side='right'caption='[[2ojw]], [[Resolution|resolution]] 2.05&Aring;' scene=''>

<table><tr><td colspan='2'>[[2ojw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OJW FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ojw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ojw OCA], [https://pdbe.org/2ojw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ojw RCSB], [https://www.ebi.ac.uk/pdbsum/2ojw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ojw ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GLNA_HUMAN GLNA_HUMAN] Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:[https://omim.org/entry/610015 610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.<ref>PMID:16267323</ref>  

[https://www.uniprot.org/uniprot/GLNA_HUMAN GLNA_HUMAN] This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.<ref>PMID:18662667</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oj/2ojw_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ojw ConSurf].

*[[Glutamine synthetase 3D structures|Glutamine synthetase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith C]]

[[Category: Berglund H]]

[[Category: Busam RD]]

[[Category: Collins R]]

[[Category: Edwards A]]

[[Category: Flodin S]]

[[Category: Flores A]]

[[Category: Graslund S]]

[[Category: Hallberg BM]]

[[Category: Hammarstrom M]]

[[Category: Hogbom M]]

[[Category: Holmberg-Schiavone L]]

[[Category: Johansson I]]

[[Category: Karlberg T]]

[[Category: Kotenyova T]]

[[Category: Moche M]]

[[Category: Nilsson ME]]

[[Category: Nordlund P]]

[[Category: Nyman T]]

[[Category: Ogg D]]

[[Category: Persson C]]

[[Category: Sagemark J]]

[[Category: Stenmark P]]

[[Category: Sundstrom M]]

[[Category: Thorsell AG]]

[[Category: Uppenberg J]]

[[Category: Van Den Berg S]]

[[Category: Wallden K]]

[[Category: Weigelt J]]