2odb: Difference between revisions

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-{{Seed}}
-[[Image:2odb.png|left|200px]]
-<!--
+==The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)==
-The line below this paragraph, containing "STRUCTURE_2odb", creates the "Structure Box" on the page.
+<StructureSection load='2odb' size='340' side='right'caption='[[2odb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2odb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODB FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_2odb|  PDB=2odb  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odb OCA], [https://pdbe.org/2odb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odb RCSB], [https://www.ebi.ac.uk/pdbsum/2odb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/2odb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2odb ConSurf].
+<div style="clear:both"></div>
-===The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)===
+==See Also==
+*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
-==About this Structure==
+== References ==
-ODB is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.]]
+[[Category: Large Structures]]
-[[Category: Burgess, N.]]
+[[Category: Arrowsmith C]]
-[[Category: Debreczeni, J E.]]
+[[Category: Burgess N]]
-[[Category: Delft, F von.]]
+[[Category: Debreczeni JE]]
-[[Category: Doyle, D.]]
+[[Category: Doyle D]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Elkins, J.]]
+[[Category: Elkins J]]
-[[Category: Eswaran, J.]]
+[[Category: Eswaran J]]
-[[Category: Gileadi, O.]]
+[[Category: Gileadi O]]
-[[Category: Knapp, S.]]
+[[Category: Knapp S]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike ACW]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Soundararajan M]]
-[[Category: Soundararajan, M.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Ugochukwu E]]
-[[Category: Ugochukwu, E.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Yang X]]
-[[Category: Yang, X.]]
+[[Category: Von Delft F]]
-[[Category: Crib]]
-[[Category: Kinase]]
-[[Category: Protein-protein complex]]
-[[Category: Sgc]]
-[[Category: Small gtpase]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:22:09 2009''