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[[Image:2odb.gif|left|200px]]


{{Structure
==The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)==
|PDB= 2odb |SIZE=350|CAPTION= <scene name='initialview01'>2odb</scene>, resolution 2.40&Aring;
<StructureSection load='2odb' size='340' side='right'caption='[[2odb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2odb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODB FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE= CDC42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odb OCA], [https://pdbe.org/2odb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odb RCSB], [https://www.ebi.ac.uk/pdbsum/2odb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odb ProSAT]</span></td></tr>
|RELATEDENTRY=[[1grn|1GRN]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odb OCA], [http://www.ebi.ac.uk/pdbsum/2odb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2odb RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/od/2odb_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2odb ConSurf].
<div style="clear:both"></div>


'''The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)'''
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
==About this Structure==
== References ==
2ODB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODB OCA].
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Burgess, N.]]
[[Category: Burgess N]]
[[Category: Debreczeni, J E.]]
[[Category: Debreczeni JE]]
[[Category: Delft, F von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Eswaran J]]
[[Category: Eswaran, J.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Knapp S]]
[[Category: Knapp, S.]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W.]]
[[Category: Soundararajan M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Soundararajan, M.]]
[[Category: Ugochukwu E]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Ugochukwu, E.]]
[[Category: Yang X]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Yang, X.]]
[[Category: crib]]
[[Category: kinase]]
[[Category: protein-protein complex]]
[[Category: sgc]]
[[Category: small gtpase]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:16:07 2008''

Latest revision as of 13:36, 30 August 2023

The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)

Structural highlights

2odb is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CDC42_HUMAN Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell. 2004 May;15(5):2205-17. Epub 2004 Feb 20. PMID:14978216 doi:10.1091/mbc.E03-07-0493
  2. ↑ Oceguera-Yanez F, Kimura K, Yasuda S, Higashida C, Kitamura T, Hiraoka Y, Haraguchi T, Narumiya S. Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis. J Cell Biol. 2005 Jan 17;168(2):221-32. Epub 2005 Jan 10. PMID:15642749 doi:10.1083/jcb.200408085
  3. ↑ Modzelewska K, Newman LP, Desai R, Keely PJ. Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. J Biol Chem. 2006 Dec 8;281(49):37527-35. Epub 2006 Oct 12. PMID:17038317 doi:10.1074/jbc.M604342200

2odb, resolution 2.40Å

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