2o20: Difference between revisions

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-[[Image:2o20.gif|left|200px]]
- {{Structure
+==Crystal structure of transcription regulator CcpA of Lactococcus lactis==
-|PDB= 2o20 |SIZE=350|CAPTION= <scene name='initialview01'>2o20</scene>, resolution 1.90&Aring;
+<StructureSection load='2o20' size='340' side='right'caption='[[2o20]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
+<table><tr><td colspan='2'>[[2o20]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O20 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-|GENE= ccpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o20 OCA], [https://pdbe.org/2o20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o20 RCSB], [https://www.ebi.ac.uk/pdbsum/2o20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o20 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9CF33_LACLA Q9CF33_LACLA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/2o20_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o20 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Catabolite control protein A (CcpA) functions as master transcriptional regulator of carbon catabolism in Firmicutes. It belongs to the family of bacterial repressor/regulator proteins. Here, the crystal structure of the 76 kDa homodimeric CcpA protein from Lactococcus lactis subsp. lactis IL1403 is presented at 1.9 A resolution in the absence of cognate DNA. The phases were derived by molecular replacement and the structure was refined to crystallographic R and R(free) factors of 0.177 and 0.211, respectively. The presence of a sulfate molecule in the direct vicinity of a putative effector-binding site in the monomer allowed the derivation of a model for the possible binding of small organic effector molecules.
-'''Crystal structure of transcription regulator CcpA of Lactococcus lactis'''
+Structure of the transcription regulator CcpA from Lactococcus lactis.,Loll B, Kowalczyk M, Alings C, Chieduch A, Bardowski J, Saenger W, Biesiadka J Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):431-6. Epub 2007, Mar 16. PMID:17372346<ref>PMID:17372346</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2o20" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-O20 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis Lactococcus lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O20 OCA].
+*[[Catabolite control protein 3D structures|Catabolite control protein 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Lactococcus lactis]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Alings, C.]]
+[[Category: Alings C]]
-[[Category: Bardowski, J.]]
+[[Category: Bardowski J]]
-[[Category: Biesiadka, J.]]
+[[Category: Biesiadka J]]
-[[Category: Chieduch, A.]]
+[[Category: Chieduch A]]
-[[Category: Kowalczyk, M.]]
+[[Category: Kowalczyk M]]
-[[Category: Loll, B.]]
+[[Category: Loll B]]
-[[Category: Saenger, W.]]
+[[Category: Saenger W]]
-[[Category: CL]]
-[[Category: SO4]]
-[[Category: ccpa]]
-[[Category: helix-turn-helix]]
-[[Category: transcriptional regulator]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:54:05 2008''