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[[Image:2nt2.jpg|left|200px]]<br /><applet load="2nt2" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2nt2, resolution 2.1&Aring;" />
'''Crystal Structure of Slingshot phosphatase 2'''<br />


==About this Structure==
==Crystal Structure of Slingshot phosphatase 2==
2NT2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NT2 OCA].  
<StructureSection load='2nt2' size='340' side='right'caption='[[2nt2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2nt2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NT2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nt2 OCA], [https://pdbe.org/2nt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nt2 RCSB], [https://www.ebi.ac.uk/pdbsum/2nt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nt2 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SSH2_HUMAN SSH2_HUMAN] Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.<ref>PMID:11832213</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/2nt2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nt2 ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Crystal structure of human slingshot phosphatase 2., Jung SK, Jeong DG, Yoon TS, Kim JH, Ryu SE, Kim SJ, Proteins. 2007 Jul 1;68(1):408-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17427953 17427953]
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Jeong, D G.]]
[[Category: Jeong DG]]
[[Category: Jung, S K.]]
[[Category: Jung SK]]
[[Category: Kim, J H.]]
[[Category: Kim JH]]
[[Category: Kim, S J.]]
[[Category: Kim SJ]]
[[Category: Ryu, S E.]]
[[Category: Ryu SE]]
[[Category: Yoon, T S.]]
[[Category: Yoon TS]]
[[Category: SO4]]
[[Category: alpha/beta hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:10:39 2008''

Latest revision as of 13:20, 30 August 2023

Crystal Structure of Slingshot phosphatase 2Crystal Structure of Slingshot phosphatase 2

Structural highlights

2nt2 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SSH2_HUMAN Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell. 2002 Jan 25;108(2):233-46. PMID:11832213

2nt2, resolution 2.10Å

Drag the structure with the mouse to rotate

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