2npt: Difference between revisions

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 <StructureSection load='2npt' size='340' side='right'caption='[[2npt]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2npt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPT FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2npt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NPT FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAP2K5, MEK5, MKK5, PRKMK5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MAP3K2, MAPKKK2, MEKK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2npt OCA], [https://pdbe.org/2npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2npt RCSB], [https://www.ebi.ac.uk/pdbsum/2npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2npt ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN]] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref>  [[https://www.uniprot.org/uniprot/M3K2_HUMAN M3K2_HUMAN]] Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.<ref>PMID:10713157</ref> <ref>PMID:16001074</ref>
+[https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 23: / Line 22: @@
 ==See Also==
 *[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]]
+*[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]]
 *[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]]
 == References ==
@@ Line 28: / Line 28: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Mitogen-activated protein kinase kinase]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C]]
+[[Category: Debreczeni J]]
-[[Category: Debreczeni, J]]
+[[Category: Edwards A]]
-[[Category: Delft, F von]]
+[[Category: Filippakopoulos P]]
-[[Category: Edwards, A]]
+[[Category: Knapp S]]
-[[Category: Filippakopoulos, P]]
+[[Category: Papagrigoriou V]]
-[[Category: Knapp, S]]
+[[Category: Sundstrom M]]
-[[Category: Papagrigoriou, V]]
+[[Category: Turnbull A]]
-[[Category: Structural genomic]]
+[[Category: Von Delft F]]
-[[Category: Sundstrom, M]]
-[[Category: Turnbull, A]]
-[[Category: Map kinase kinase 5]]
-[[Category: Map2k5]]
-[[Category: Map3k2]]
-[[Category: Mapk/erk kinase kinase 2]]
-[[Category: Mapkkk2]]
-[[Category: Mek kinase 2]]
-[[Category: Mek5]]
-[[Category: Mekk2]]
-[[Category: Mekk2b]]
-[[Category: Mitogen activated protein kinase kinase 5]]
-[[Category: Mitogen activated protein kinase kinase kinase 2]]
-[[Category: Mkk5]]
-[[Category: Phox]]
-[[Category: Phox-domain]]
-[[Category: Prkmk5]]
-[[Category: Sgc]]
-[[Category: Transferase]]