2ik8: Difference between revisions

<StructureSection load='2ik8' size='340' side='right'caption='[[2ik8]], [[Resolution|resolution]] 2.71&Aring;' scene=''>

<table><tr><td colspan='2'>[[2ik8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IK8 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.71&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ik8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ik8 OCA], [https://pdbe.org/2ik8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ik8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ik8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ik8 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>  

*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith C]]

[[Category: Debreczeni J]]

[[Category: Doyle DA]]

[[Category: Edwards A]]

[[Category: Gorrec F]]

[[Category: Papagrigoriou E]]

[[Category: Soundararajan M]]

[[Category: Sundstrom M]]

[[Category: Turnbull AP]]

[[Category: Weigelt J]]

[[Category: Von Delft F]]