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[[Image:2igw.jpg|left|200px]]


{{Structure
==CYCLOPHILIN 3 complexed with DIPEPTIDE GLY-PRO==
|PDB= 2igw |SIZE=350|CAPTION= <scene name='initialview01'>2igw</scene>, resolution 1.78&Aring;
<StructureSection load='2igw' size='340' side='right'caption='[[2igw]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene>
<table><tr><td colspan='2'>[[2igw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGW FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igw OCA], [https://pdbe.org/2igw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igw RCSB], [https://www.ebi.ac.uk/pdbsum/2igw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igw ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2igw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igw OCA], [http://www.ebi.ac.uk/pdbsum/2igw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2igw RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/CYP3_CAEEL CYP3_CAEEL] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/2igw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2igw ConSurf].
<div style="clear:both"></div>


'''CYCLOPHILIN 3 complexed with DIPEPTIDE GLY-PRO'''
==See Also==
 
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2IGW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGW OCA].
 
==Reference==
Experimental determination of van der waals energies in a biological system., Wear MA, Kan D, Rabu A, Walkinshaw MD, Angew Chem Int Ed Engl. 2007;46(34):6453-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17654646 17654646]
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Kan D]]
[[Category: Kan, D.]]
[[Category: isomerase]]
[[Category: rotamase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:44:14 2008''

Latest revision as of 13:10, 30 August 2023

CYCLOPHILIN 3 complexed with DIPEPTIDE GLY-PROCYCLOPHILIN 3 complexed with DIPEPTIDE GLY-PRO

Structural highlights

2igw is a 1 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.78Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CYP3_CAEEL PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2igw, resolution 1.78Å

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