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[[Image:2igi.png|left|200px]]


{{STRUCTURE_2igi|  PDB=2igi  |  SCENE=  }}
==Crystal Structure of E. coli Oligoribonuclease==
 
<StructureSection load='2igi' size='340' side='right'caption='[[2igi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Crystal Structure of E. coli Oligoribonuclease===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2igi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IGI FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[2igi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IGI OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2igi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2igi OCA], [https://pdbe.org/2igi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2igi RCSB], [https://www.ebi.ac.uk/pdbsum/2igi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2igi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ORN_ECOLI ORN_ECOLI] 3'-to-5' exoribonuclease specific for small oligoribonucleotides 2 to 5 nucleotides in length, as well as small (2 to 5 nucleotides) ssDNA oligomers. Probably responsible for the final step in mRNA degradation.<ref>PMID:9573169</ref> <ref>PMID:7608090</ref> <ref>PMID:16682444</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ig/2igi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2igi ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ribonuclease|Ribonuclease]]
*[[Exonuclease 3D structures|Exonuclease 3D structures]]
[[Category: Escherichia coli k-12]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
[[Category: Malhotra, A.]]
== References ==
[[Category: Zuo, Y.]]
<references/>
[[Category: Exonuclease]]
__TOC__
[[Category: Exoribonuclease]]
</StructureSection>
[[Category: Hydrolase]]
[[Category: Escherichia coli K-12]]
[[Category: Mrna decay]]
[[Category: Large Structures]]
[[Category: Nuclease]]
[[Category: Malhotra A]]
[[Category: Ribonuclease]]
[[Category: Zuo Y]]
[[Category: Rnase]]

Latest revision as of 13:10, 30 August 2023

Crystal Structure of E. coli OligoribonucleaseCrystal Structure of E. coli Oligoribonuclease

Structural highlights

2igi is a 2 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ORN_ECOLI 3'-to-5' exoribonuclease specific for small oligoribonucleotides 2 to 5 nucleotides in length, as well as small (2 to 5 nucleotides) ssDNA oligomers. Probably responsible for the final step in mRNA degradation.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhang X, Zhu L, Deutscher MP. Oligoribonuclease is encoded by a highly conserved gene in the 3'-5' exonuclease superfamily. J Bacteriol. 1998 May;180(10):2779-81. PMID:9573169
  2. ↑ Yu D, Deutscher MP. Oligoribonuclease is distinct from the other known exoribonucleases of Escherichia coli. J Bacteriol. 1995 Jul;177(14):4137-9. PMID:7608090
  3. ↑ Mechold U, Ogryzko V, Ngo S, Danchin A. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. Nucleic Acids Res. 2006 May 8;34(8):2364-73. Print 2006. PMID:16682444 doi:http://dx.doi.org/10.1093/nar/gkl247

2igi, resolution 1.70Å

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