2ic5: Difference between revisions

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-[[Image:2ic5.gif|left|200px]]
- {{Structure
+==Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.==
-|PDB= 2ic5 |SIZE=350|CAPTION= <scene name='initialview01'>2ic5</scene>, resolution 1.90&Aring;
+<StructureSection load='2ic5' size='340' side='right'caption='[[2ic5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene> and <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>
+<table><tr><td colspan='2'>[[2ic5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IC5 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-|GENE= RAC3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ic5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ic5 OCA], [https://pdbe.org/2ic5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ic5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ic5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ic5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/2ic5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ic5 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.'''
+==See Also==
+*[[Rac 3D structures|Rac 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-IC5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IC5 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bunkoczi G]]
-[[Category: Burgess, N.]]
+[[Category: Burgess N]]
-[[Category: Colebrook, S.]]
+[[Category: Colebrook S]]
-[[Category: Delft, F von.]]
+[[Category: Doyle D]]
-[[Category: Doyle, D.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Elkins J]]
-[[Category: Elkins, J.]]
+[[Category: Fedorov O]]
-[[Category: Fedorov, O.]]
+[[Category: Gileadi C]]
-[[Category: Gileadi, C.]]
+[[Category: Gileadi O]]
-[[Category: Gileadi, O.]]
+[[Category: Sundstrom M]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Ugochukwu E]]
-[[Category: Sundstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Ugochukwu, E.]]
+[[Category: Yang X]]
-[[Category: Weigelt, J.]]
+[[Category: Zao Y]]
-[[Category: Yang, X.]]
+[[Category: Von Delft F]]
-[[Category: Zao, Y.]]
-[[Category: BTB]]
-[[Category: CL]]
-[[Category: GDP]]
-[[Category: GNP]]
-[[Category: MG]]
-[[Category: gppnhp]]
-[[Category: gtpase rac3]]
-[[Category: p21 rac]]
-[[Category: ras-related c3 botulinum toxin substrate 3]]
-[[Category: sgc]]
-[[Category: signalling protein]]
-[[Category: small gtp binding protein]]
-[[Category: structural genomic]]
-[[Category: structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:27:45 2008''