2hda: Difference between revisions

<StructureSection load='2hda' size='340' side='right'caption='[[2hda]], [[Resolution|resolution]] 1.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[2hda]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HDA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hda OCA], [https://pdbe.org/2hda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hda RCSB], [https://www.ebi.ac.uk/pdbsum/2hda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hda ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/YES_HUMAN YES_HUMAN] Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.<ref>PMID:11901164</ref> <ref>PMID:17053785</ref> <ref>PMID:18479465</ref> <ref>PMID:19276087</ref> <ref>PMID:21566460</ref> <ref>PMID:21713032</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/2hda_consurf.spt"</scriptWhenChecked>

*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Camara-Artigas A]]

[[Category: Luque I]]

[[Category: Martin-Garcia JM]]

[[Category: Mateo PL]]

[[Category: Ruiz-Sanz J]]