2h2t: Difference between revisions

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[[Image:2h2t.png|left|200px]]


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==CD23 Lectin domain, Calcium 2+-bound==
The line below this paragraph, containing "STRUCTURE_2h2t", creates the "Structure Box" on the page.
<StructureSection load='2h2t' size='340' side='right'caption='[[2h2t]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2h2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H2T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
{{STRUCTURE_2h2t|  PDB=2h2t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h2t OCA], [https://pdbe.org/2h2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h2t RCSB], [https://www.ebi.ac.uk/pdbsum/2h2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h2t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FCER2_HUMAN FCER2_HUMAN] Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/2h2t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h2t ConSurf].
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== Publication Abstract from PubMed ==
CD23, the low-affinity receptor for IgE (Fc epsilonRII), regulates IgE synthesis and also mediates IgE-dependent antigen transport and processing. CD23 is a unique Fc receptor belonging to the C-type lectin-like domain superfamily and binds IgE in an unusual, non-lectin-like manner, requiring calcium but not carbohydrate. We have solved the high-resolution crystal structures of the human CD23 lectin domain in the presence and absence of Ca2+. The crystal structures differ significantly from a previously determined NMR structure and show that calcium binding occurs at the principal binding site, but not at an auxiliary site that appears to be absent in human CD23. Conformational differences between the apo and Ca2+ bound structures suggest how IgE-Fc binding can be both calcium-dependent and carbohydrate-independent.


===CD23 Lectin domain, Calcium 2+-bound===
Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.,Wurzburg BA, Tarchevskaya SS, Jardetzky TS Structure. 2006 Jun;14(6):1049-58. PMID:16765898<ref>PMID:16765898</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2h2t" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_16765898}}, adds the Publication Abstract to the page
*[[CD23|CD23]]
(as it appears on PubMed at http://www.pubmed.gov), where 16765898 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_16765898}}
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</StructureSection>
==About this Structure==
[[2h2t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H2T OCA].
 
==Reference==
<ref group="xtra">PMID:016765898</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Wurzburg, B A.]]
[[Category: Large Structures]]
[[Category: C-type lectin]]
[[Category: Wurzburg BA]]
[[Category: Calcium-bound]]
[[Category: Immune system]]
[[Category: Lectin domain]]
[[Category: Low affinity ige receptor]]

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