2gs3: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2gs3.gif|left|200px]]
-<!--
+==Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)==
-The line below this paragraph, containing "STRUCTURE_2gs3", creates the "Structure Box" on the page.
+<StructureSection load='2gs3' size='340' side='right'caption='[[2gs3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2gs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GS3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-{{STRUCTURE_2gs3|  PDB=2gs3  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gs3 OCA], [https://pdbe.org/2gs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gs3 RCSB], [https://www.ebi.ac.uk/pdbsum/2gs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gs3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gs3_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gs3 ConSurf].
+<div style="clear:both"></div>
-'''Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)'''
+==See Also==
+*[[Glutathione peroxidase|Glutathione peroxidase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-GS3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GS3 OCA].
 [[Category: Homo sapiens]]
-[[Category: Phospholipid-hydroperoxide glutathione peroxidase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Arrowsmith C]]
-[[Category: Arrowsmith, C.]]
+[[Category: Edwards A]]
-[[Category: Delft, F Von.]]
+[[Category: Gileadi O]]
-[[Category: Edwards, A.]]
+[[Category: Johansson C]]
-[[Category: Gileadi, O.]]
+[[Category: Kavanagh KL]]
-[[Category: Johansson, C.]]
+[[Category: Oppermann U]]
-[[Category: Kavanagh, K L.]]
+[[Category: Rojkova A]]
-[[Category: Oppermann, U.]]
+[[Category: Sundstrom M]]
-[[Category: Rojkova, A.]]
+[[Category: Weigelt J]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Von Delft F]]
-[[Category: Sundstrom, M.]]
-[[Category: Weigelt, J.]]
-[[Category: Gpx4]]
-[[Category: Gshpx-4,phospholipid hydroperoxide]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:27:15 2008''