2gs3: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2gs3.gif|left|200px]]


{{Structure
==Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)==
|PDB= 2gs3 |SIZE=350|CAPTION= <scene name='initialview01'>2gs3</scene>, resolution 1.90&Aring;
<StructureSection load='2gs3' size='340' side='right'caption='[[2gs3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
<table><tr><td colspan='2'>[[2gs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GS3 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE= GPX4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gs3 OCA], [https://pdbe.org/2gs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gs3 RCSB], [https://www.ebi.ac.uk/pdbsum/2gs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gs3 ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gs3 OCA], [http://www.ebi.ac.uk/pdbsum/2gs3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gs3 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gs3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gs3 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)'''
==See Also==
 
*[[Glutathione peroxidase|Glutathione peroxidase]]
 
__TOC__
==About this Structure==
</StructureSection>
2GS3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GS3 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phospholipid-hydroperoxide glutathione peroxidase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Edwards A]]
[[Category: Delft, F Von.]]
[[Category: Gileadi O]]
[[Category: Edwards, A.]]
[[Category: Johansson C]]
[[Category: Gileadi, O.]]
[[Category: Kavanagh KL]]
[[Category: Johansson, C.]]
[[Category: Oppermann U]]
[[Category: Kavanagh, K L.]]
[[Category: Rojkova A]]
[[Category: Oppermann, U.]]
[[Category: Sundstrom M]]
[[Category: Rojkova, A.]]
[[Category: Weigelt J]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Von Delft F]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt, J.]]
[[Category: gpx4]]
[[Category: gshpx-4,phospholipid hydroperoxide]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:20:46 2008''

Latest revision as of 12:46, 30 August 2023

Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)

Structural highlights

2gs3 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GPX4_HUMAN Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2gs3, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2gs3&oldid=3850502"