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[[Image:2gf0.gif|left|200px]]


{{Structure
==The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state==
|PDB= 2gf0 |SIZE=350|CAPTION= <scene name='initialview01'>2gf0</scene>, resolution 1.90&Aring;
<StructureSection load='2gf0' size='340' side='right'caption='[[2gf0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>
<table><tr><td colspan='2'>[[2gf0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GF0 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE= DIRAS1, GBTS1, RIG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gf0 OCA], [https://pdbe.org/2gf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2gf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gf0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DIRA1_HUMAN DIRA1_HUMAN] Displays low GTPase activity and exist predominantly in the GTP-bound form.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/2gf0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gf0 ConSurf].
<div style="clear:both"></div>


'''The crystal structure of the human DiRas1 GTPase in the inactive GDP bound state'''
==See Also==
 
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
__TOC__
==Disease==
</StructureSection>
Known disease associated with this structure: Gaze palsy, horizontal, with progressive scoliosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608630 608630]]
 
==About this Structure==
2GF0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF0 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Delft, F von.]]
[[Category: Doyle D]]
[[Category: Doyle, D.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Elkins J]]
[[Category: Elkins, J.]]
[[Category: Fedorov O]]
[[Category: Fedorov, O.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Niesen FE]]
[[Category: Niesen, F E.]]
[[Category: Papagrigoriou E]]
[[Category: Papagrigoriou, E.]]
[[Category: Salah E]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Schoch G]]
[[Category: Salah, E.]]
[[Category: Sundstrom M]]
[[Category: Schoch, G.]]
[[Category: Turnbull AP]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Turnbull, A P.]]
[[Category: Wen-Hwa L]]
[[Category: Weigelt, J.]]
[[Category: Yang X]]
[[Category: Wen-Hwa, L.]]
[[Category: Von Delft F]]
[[Category: Yang, X.]]
[[Category: GDP]]
[[Category: MG]]
[[Category: dira]]
[[Category: gdp/gtp binding]]
[[Category: gtp hydrolysis]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:03:54 2008''

Latest revision as of 12:39, 30 August 2023

The crystal structure of the human DiRas1 GTPase in the inactive GDP bound stateThe crystal structure of the human DiRas1 GTPase in the inactive GDP bound state

Structural highlights

2gf0 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DIRA1_HUMAN Displays low GTPase activity and exist predominantly in the GTP-bound form.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2gf0, resolution 1.90Å

Drag the structure with the mouse to rotate

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OCA
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