2gc8: Difference between revisions
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==Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase== | ==Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase== | ||
<StructureSection load='2gc8' size='340' side='right' caption='[[2gc8]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2gc8' size='340' side='right'caption='[[2gc8]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gc8]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2gc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GC8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=885:1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE'>885</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gc8 OCA], [https://pdbe.org/2gc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gc8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gc8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q99AU2_9HEPC Q99AU2_9HEPC] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Hepacivirus C]] | ||
[[Category: Agarwal | [[Category: Large Structures]] | ||
[[Category: Bard | [[Category: Agarwal A]] | ||
[[Category: Chopra | [[Category: Bard J]] | ||
[[Category: Ciszewski | [[Category: Chopra R]] | ||
[[Category: Curran | [[Category: Ciszewski G]] | ||
[[Category: Ellingboe | [[Category: Curran KJ]] | ||
[[Category: Feld | [[Category: Ellingboe JW]] | ||
[[Category: Gopalsamy | [[Category: Feld B]] | ||
[[Category: Howe | [[Category: Gopalsamy A]] | ||
[[Category: Krishnamurthy | [[Category: Howe AY]] | ||
[[Category: Lim | [[Category: Krishnamurthy G]] | ||
[[Category: Mansour | [[Category: Lim K]] | ||
[[Category: | [[Category: Mansour TS]] | ||
[[Category: | [[Category: O'connell J]] | ||
[[Category: | [[Category: Orlowski M]] | ||
[[Category: | [[Category: Shi M]] | ||
[[Category: | [[Category: Sukits SF]] | ||
[[Category: Svenson K]] | |||