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{{STRUCTURE_2fe5|  PDB=2fe5  |  SCENE=  }}
===The Crystal Structure of the Second PDZ Domain of Human DLG3===


==Disease==
==The Crystal Structure of the Second PDZ Domain of Human DLG3==
[[http://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN]] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[http://omim.org/entry/300850 300850]]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref>  
<StructureSection load='2fe5' size='340' side='right'caption='[[2fe5]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[2fe5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FE5 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN]] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fe5 OCA], [https://pdbe.org/2fe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fe5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fe5 ProSAT]</span></td></tr>
[[2fe5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FE5 OCA].  
</table>
 
== Disease ==
==Reference==
[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[https://omim.org/entry/300850 300850]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref>  
<references group="xtra"/><references/>
== Function ==
[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fe5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fe5 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Large Structures]]
[[Category: Berridge, G.]]
[[Category: Arrowsmith C]]
[[Category: Bray, J.]]
[[Category: Berridge G]]
[[Category: Bunkoczi, G.]]
[[Category: Bray J]]
[[Category: Colebrook, S.]]
[[Category: Bunkoczi G]]
[[Category: Debreczeni, J.]]
[[Category: Colebrook S]]
[[Category: Delft, F von.]]
[[Category: Debreczeni J]]
[[Category: Doyle, D.]]
[[Category: Doyle D]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Elkins, J.]]
[[Category: Elkins J]]
[[Category: Gorrec, F.]]
[[Category: Gorrec F]]
[[Category: Phillips, C.]]
[[Category: Phillips C]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Salah E]]
[[Category: Salah, E.]]
[[Category: Savitsky P]]
[[Category: Savitsky, P.]]
[[Category: Schoch G]]
[[Category: Schoch, G.]]
[[Category: Smee C]]
[[Category: Smee, C.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Turnbull A]]
[[Category: Turnbull, A.]]
[[Category: Ugochukwu E]]
[[Category: Ugochukwu, E.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Dlg3]]
[[Category: Human]]
[[Category: Pdz domain]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Structural protein]]

Latest revision as of 12:25, 30 August 2023

The Crystal Structure of the Second PDZ Domain of Human DLG3The Crystal Structure of the Second PDZ Domain of Human DLG3

Structural highlights

2fe5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

DLG3_HUMAN Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300850. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.[1]

Function

DLG3_HUMAN Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Tarpey P, Parnau J, Blow M, Woffendin H, Bignell G, Cox C, Cox J, Davies H, Edkins S, Holden S, Korny A, Mallya U, Moon J, O'Meara S, Parker A, Stephens P, Stevens C, Teague J, Donnelly A, Mangelsdorf M, Mulley J, Partington M, Turner G, Stevenson R, Schwartz C, Young I, Easton D, Bobrow M, Futreal PA, Stratton MR, Gecz J, Wooster R, Raymond FL. Mutations in the DLG3 gene cause nonsyndromic X-linked mental retardation. Am J Hum Genet. 2004 Aug;75(2):318-24. Epub 2004 Jun 7. PMID:15185169 doi:10.1086/422703

2fe5, resolution 1.10Å

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