2fe5: Difference between revisions

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-[[Image:2fe5.png|left|200px]]
-{{STRUCTURE_2fe5|  PDB=2fe5  |  SCENE=  }}
+==The Crystal Structure of the Second PDZ Domain of Human DLG3==
+<StructureSection load='2fe5' size='340' side='right'caption='[[2fe5]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
-===The Crystal Structure of the Second PDZ Domain of Human DLG3===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2fe5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FE5 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[2fe5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FE5 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fe5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fe5 OCA], [https://pdbe.org/2fe5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fe5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fe5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fe5 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:[https://omim.org/entry/300850 300850]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:15185169</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/DLG3_HUMAN DLG3_HUMAN] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fe/2fe5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fe5 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.]]
+[[Category: Large Structures]]
-[[Category: Berridge, G.]]
+[[Category: Arrowsmith C]]
-[[Category: Bray, J.]]
+[[Category: Berridge G]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bray J]]
-[[Category: Colebrook, S.]]
+[[Category: Bunkoczi G]]
-[[Category: Debreczeni, J.]]
+[[Category: Colebrook S]]
-[[Category: Delft, F von.]]
+[[Category: Debreczeni J]]
-[[Category: Doyle, D.]]
+[[Category: Doyle D]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Elkins, J.]]
+[[Category: Elkins J]]
-[[Category: Gorrec, F.]]
+[[Category: Gorrec F]]
-[[Category: Phillips, C.]]
+[[Category: Phillips C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Salah E]]
-[[Category: Salah, E.]]
+[[Category: Savitsky P]]
-[[Category: Savitsky, P.]]
+[[Category: Schoch G]]
-[[Category: Schoch, G.]]
+[[Category: Smee C]]
-[[Category: Smee, C.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Turnbull A]]
-[[Category: Turnbull, A.]]
+[[Category: Ugochukwu E]]
-[[Category: Ugochukwu, E.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Von Delft F]]
-[[Category: Dlg3]]
-[[Category: Human]]
-[[Category: Pdz domain]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Structural protein]]