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[[Image:2f8n.gif|left|200px]]


{{Structure
==2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes==
|PDB= 2f8n |SIZE=350|CAPTION= <scene name='initialview01'>2f8n</scene>, resolution 2.9&Aring;
<StructureSection load='2f8n' size='340' side='right'caption='[[2f8n]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
<table><tr><td colspan='2'>[[2f8n]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8N FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
|GENE=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8n OCA], [https://pdbe.org/2f8n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8n RCSB], [https://www.ebi.ac.uk/pdbsum/2f8n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8n ProSAT]</span></td></tr>
|DOMAIN=
</table>
|RELATEDENTRY=[[1aoi|1AOI]], [[1u35|1U35]], [[1f66|1F66]]
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f8n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8n OCA], [http://www.ebi.ac.uk/pdbsum/2f8n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f8n RCSB]</span>
[https://www.uniprot.org/uniprot/H2B3A_MOUSE H2B3A_MOUSE] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f8n ConSurf].
<div style="clear:both"></div>


'''2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes'''
==See Also==
 
*[[Histone 3D structures|Histone 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2F8N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8N OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Chakravarthy, S.]]
[[Category: Chakravarthy S]]
[[Category: Luger, K.]]
[[Category: Luger K]]
[[Category: chromatin]]
[[Category: crystallography]]
[[Category: histone variant]]
[[Category: macroh2a]]
[[Category: ncp]]
[[Category: nucleosome]]
[[Category: x-ray structure]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:23 2008''

Latest revision as of 12:22, 30 August 2023

2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes

Structural highlights

2f8n is a 10 chain structure with sequence from Homo sapiens, Mus musculus and Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.9Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

H2B3A_MOUSE Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2f8n, resolution 2.90Å

Drag the structure with the mouse to rotate

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