2f8d: Difference between revisions

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==BenM effector-Binding domain crystallized from high pH conditions==
==BenM effector-Binding domain crystallized from high pH conditions==
<StructureSection load='2f8d' size='340' side='right' caption='[[2f8d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2f8d' size='340' side='right'caption='[[2f8d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2f8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acibi Acibi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F8D FirstGlance]. <br>
<table><tr><td colspan='2'>[[2f8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baylyi Acinetobacter baylyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f6g|2f6g]], [[2f6p|2f6p]], [[2f78|2f78]], [[2f7a|2f7a]], [[2f7b|2f7b]], [[2f7c|2f7c]], [[2f97|2f97]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">benM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=202950 ACIBI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8d OCA], [https://pdbe.org/2f8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8d RCSB], [https://www.ebi.ac.uk/pdbsum/2f8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8d OCA], [http://pdbe.org/2f8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2f8d RCSB], [http://www.ebi.ac.uk/pdbsum/2f8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BENM_ACIAD BENM_ACIAD]] Positive regulator of the ben and cat genes for benzoate degradation. BenM is necessary for ben gene expression but not for expression of the cat genes, which can be regulated by CatM. Binds to the inducers cis,cis-muconate and benzoate.  
[https://www.uniprot.org/uniprot/BENM_ACIAD BENM_ACIAD] Positive regulator of the ben and cat genes for benzoate degradation. BenM is necessary for ben gene expression but not for expression of the cat genes, which can be regulated by CatM. Binds to the inducers cis,cis-muconate and benzoate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8d_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8d_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acibi]]
[[Category: Acinetobacter baylyi]]
[[Category: Ezezika, O C]]
[[Category: Large Structures]]
[[Category: Haddad, S]]
[[Category: Ezezika OC]]
[[Category: Momany, C]]
[[Category: Haddad S]]
[[Category: Neidle, E L]]
[[Category: Momany C]]
[[Category: Benm]]
[[Category: Neidle EL]]
[[Category: Effector binding domain]]
[[Category: Gene regulation]]
[[Category: Inducer binding domain]]
[[Category: Lttr]]
[[Category: Lysr-type transcriptional regulator]]
[[Category: Tetramerization]]

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